Catalog11 refs
ACTH
Nootropic & NeuroOtherResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Overview
Synthetic version of the first 24 amino acids of the body's natural stress hormone ACTH. Binds MC2R receptors on adrenal cortex cells to stimulate cortisol and corticosteroid synthesis. Used as an FDA-approved diagnostic tool to assess adrenal reserve and therapeutically for conditions such as infantile spasms and nephrotic syndrome.
Primary Uses
Diagnostic testing of adrenal gland function
Assessment of adrenal insufficiency
Treatment of infantile spasms
Treatment of nephrotic syndrome
Adrenal axis testing
Steroidogenesis research
Anti-inflammatory signaling
Pituitary-adrenal physiology
Adrenal insufficiency diagnosis and treatment
Cortisol synthesis and release
Adrenal gland growth
Protocol Reference
Dose
25–250 mcg IM/SubQ (research protocols vary by indication)
Frequency
Single dose (diagnostic) or per protocol (therapeutic)
Half-life
Native ACTH only minutes in plasma; depot formulations act longer
Route
Subcutaneous · Intramuscular
Evidence
Phase 4, FDA Approved, Moderate / FDA approved formulations available for adrenal insufficiency diagnosis and treatment (disputed)
Research References· 15
Research Models
Human
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