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BPC-157

Healing & RecoverytherapeuticHealingResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
4-6 hours
Half-life
49
Uses
250
Typical
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JointsMusclesCirculation
Overview

BPC-157 is a synthetic 15-amino-acid peptide based on a fragment of a protective protein found in human gastric juice. It is studied primarily in animals for tendon, ligament, gut, and tissue healing, with hundreds of preclinical papers. The leading hypothesis is that BPC-157 promotes new blood vessel growth by upregulating the VEGFR2 receptor and tapping into the nitric oxide system through the Akt-eNOS pathway. It is not approved by any regulator for any use, and human evidence is limited to a handful of small pilot studies.

Primary Uses
Wound healing
Tendon repair
Gut health and mucosal protection
Tissue repair and recovery
Ulcer healing and gut barrier recovery
Inflammation reduction at injury sites
Vascular and nitric oxide pathway modulation
Pain and injury signaling modulation
tissue repair and regeneration
healing
gut health
leaky gut
IBS
gastric inflammation
muscle tears
tendon issues
joint problems
general tissue repair and protection
Gastrointestinal repair
Tendon and ligament healing
Angiogenesis and nitric-oxide signaling
Inflammation modulation
Musculoskeletal soft tissue healing
Central nervous system effects
Cardiovascular support
Knee pain (intra-articular injection)
Gut-brain axis and neuroregeneration
Tendon healing
Muscle recovery
Angiogenesis
Neuroprotection
Spinal cord injury recovery
Peripheral nerve regeneration
Ulcer protection
Intestinal repair
Mucosal healing
Wound Healing Acceleration
Tendon and Ligament Repair
Gastrointestinal Protection
Anti-Inflammatory Effects
Bone Healing Enhancement
Neuroprotective Effects
Muscle healing
Gut lining repair
Bone healing
Liver injury repair
Nervous system injury repair
Knee pain (pilot study)
Interstitial cystitis (pilot study)
Protocol Reference
Dose
250–500 mcg daily
Frequency
Once Daily Or Split Into Twice Daily (morning And Evening)
Half-life
4-6 hours
Route
Subcutaneous · Oral
Evidence
Animal Models Primary / Phase 2 / preclinical / Extensively Studied / Limited human clinical data available, primarily studied in animal models / Preclinical (disputed)
Research References· 35
Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth
PubMedPMID 14567479. Journal of Orthopaedic Research, 2003.
Stable gastric pentadecapeptide BPC 157 — NO-system relation
PubMedPMID 23701547. Current Pharmaceutical Design, 2014.
Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain demyelination
PubMedPMID 24304574. Journal of Physiology and Pharmacology, 2013.
Research Models
DogHumanIn vitroMouseRatanimalshumans (pilot studies only)
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