Catalog10 refs
Cortagen
Immune ModulationCognition, Mood & NeuroprotectionBioregulatorsBioregulatoryResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Circulationnervesneural tissue
Overview
Synthetic tetrapeptide (Ala-Glu-Asp-Pro, AEDP) from Vladimir Khavinson's Russian peptide bioregulator program, designed as the defined-sequence stand-in for Cortexin, an older cattle brain cortex extract used in Russian neurology. Studied mostly for nerve repair, brain function and aging. Proposed mechanism involves short peptides entering the cell nucleus to bind directly to DNA and histone proteins, switching specific genes on or off to nudge aged or damaged cells toward a more youthful gene-expression pattern. Target tissue is the brain cortex, where it is hypothesized to support neuron survival and repair.
Primary Uses
Regulating brain cortex function
Supporting cognitive function in aging
Protecting brain cells
Normalizing gene expression in cerebral cortex cells
Restoring age-related decline in cognitive function
Modulating expression of genes involved in neuronal function and neurotransmitter metabolism
Normalizing cortical bioelectrical activity
Improving cognitive processing speed and attention in elderly subjects
Reducing age-related accumulation of lipofuscin and neuronal degeneration markers
Supporting cortical cell viability
Improving antioxidant defense in brain tissue
Reducing oxidative stress
Immune modulation
Anti-inflammatory research
Cortisol regulation studies
Autoimmune disease models
Nerve regeneration (sciatic nerve)
Brain ischemia correction
Gene expression regulation
Ischemic brain injury recovery
Nerve regeneration
Neuroinflammation regulation
Autoimmune modulation
IL-2 stimulation
Oxidative balance restoration
Brain aging support
Central nervous system function regulation
Adrenal and nervous system research
Support adrenal gland and nervous system function
Nerve repair
Brain function support
Neuroprotection
Anti-aging
Neuron survival and repair
Protocol Reference
Dose
10–30 mcg per injection
Frequency
Variable
Half-life
~15 Minutes
Route
Subcutaneous · Intravenous
Evidence
Preclinical / Moderate Research (disputed)
Research References· 14
Epigenetic Regulation of “Aged” Heterochromatin by Peptide Bioregulator Cortagen↗
DOIInternational Journal of Peptide Research and Therapeutics2014Lezhava T, Monaselidze J, Jokhadze T, et al.
Research Models
HumanMouseRatRussia Approved
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