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VIP (Vasoactive Intestinal Peptide)

Immune ModulationImmune & InflammationtherapeuticResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
~1 minute in plasma
Half-life
12
Uses
Intranasal: 50
Typical
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Overview

VIP is a 28-amino-acid neuropeptide belonging to the secretin/glucagon superfamily. It functions as a neurotransmitter and neuromodulator with broad immunomodulatory, vasodilatory, and neuroprotective properties. VIP is distributed throughout the central and peripheral nervous systems, gastrointestinal tract, and immune tissues, and is researched for inflammatory conditions, autoimmune diseases, and neurodegenerative disorders.

Primary Uses
Anti-inflammatory therapy
Autoimmune conditions
Neurodegenerative conditions
Neuroprotection against toxic insults and oxidative stress
Circadian rhythm regulation
Intestinal barrier function and mucosal immunity support
Chronic inflammatory response syndrome (CIRS)
Mold illness and biotoxin exposure
Pulmonary issues
Inflammatory and autoimmune conditions
Neuroimmune interactions research
Gut-brain axis signaling research
Protocol Reference
Dose
Intranasal: 50 mcg per nostril; Subcutaneous: 50–100 mcg
Frequency
Intranasal 4× daily; Subcutaneous 1–2× daily
Half-life
~1 minute in plasma
Route
intranasal · subcutaneous
Evidence
Phase 3
Research References· 2
Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions
PubMedPMID 22552839. Amino Acids, 2013.
Polypeptide with broad biological activity: isolation from small intestine
PubMedPMID 4988015. Science, 1970.
Research Models
HumanPorcine
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