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AICAR

MetabolicResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Not Well Characterized
Half-life
8
Uses
1-3mg
Typical
Body Map
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Overview

Also known as AICA Ribonucleotide or Acadesine. An AMPK activator studied as an exercise mimetic for metabolic adaptation, endurance, and fat oxidation research.

Primary Uses
AMPK activation
Exercise mimetic research
Metabolic adaptation
Endurance and fat oxidation studies
Cardioprotection
Diabetic polyneuropathy prevention and reversal
Osteoarthritis treatment via macrophage metabolic reprogramming
Postoperative abdominal adhesion reduction
Protocol Reference
Dose
1-3mg/day (conservative); up to 25mg/day (aggressive). Dosing protocols range from 1-25mg per day.
Frequency
Once Daily, 30 Minutes Before Workout
Half-life
Not Well Characterized
Route
Subcutaneous
Research References· 16
Figure 4—figure supplement 3. Effect of AICAR on 6-week differentiated neurons.↗
DOI- Crossref
Figure 4—figure supplement 2. Effect of AICAR on neuron differentiation.↗
DOI- Crossref
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.↗
PubMedPMID 40616103J Nanobiotechnology2025Fu Y, Hou J, Yang Q, Lin Y, et al.
Research Models
HumanRat
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AICAR (Acadesine)
AMPK Activation · Fatty Acid Oxidation
Metabolic
Amycretin
obesity · type 2 diabetes
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