DSIP

Healing & RecoveryNootropic & NeuronootropicAnti-AgingResearch use only

Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.

Approximately 7-15 minutes in plasma/in vitro

Half-life

Uses

250 mcg

Typical

Body Map

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Overview

Delta Sleep Inducing Peptide (DSIP) is a small naturally occurring nonapeptide (sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated in the 1970s from the blood of sleeping rabbits. It acts as a modulator influencing slow-wave sleep, neurotransmitter levels, circadian rhythm, hormone release (including growth hormone), and stress responses. It does not have one clear receptor of its own. Despite five decades of study it has no regulatory approval and the human evidence for it as a sleep aid is weak and inconsistent.

Primary Uses

Sleep promotion

Stress reduction

Hormone regulation

Delta (slow-wave) sleep promotion

Circadian rhythm normalization

Pain modulation

Sleep normalization — promotes delta-wave (deep) sleep and normalizes sleep architecture in subjects with disrupted sleep patterns

Stress modulation — reduces stress-induced cortisol elevation and normalizes ACTH levels

Pain modulation — interacts with opioid systems, showing analgesic effects in some studies

Withdrawal support — explored for alcohol and opioid withdrawal symptom management

Sleep architecture studies