Catalog6 refs
DSIP (Delta Sleep Inducing Peptide)
Nootropic & NeuroCognition, Mood & NeuroprotectionnootropicSleep & Stress ModulatorResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Overview
A nine-amino-acid neuropeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from rabbit cerebral venous blood in 1977. Acts as a sleep-wake modulator that normalizes disrupted sleep patterns rather than directly causing sedation. Also influences stress physiology, pain processing, and hormonal regulation.
Primary Uses
Sleep promotion
Stress reduction
Hormone regulation
Promoting delta (slow-wave) sleep
Circadian rhythm normalization
Reducing stress hormone release and cortisol levels
Pain modulation
Sleep normalization (promotes delta-wave/deep sleep, normalizes sleep architecture)
Stress modulation (reduces stress-induced cortisol elevation, normalizes ACTH levels)
Pain modulation (interacts with opioid systems, analgesic effects)
Withdrawal support (alcohol and opioid withdrawal symptom management)
Deep Sleep Enhancement
Sleep Efficiency
Natural Sleep Architecture
Stress Response Modulation
Mood Stabilization
Anxiety Reduction
Withdrawal Support
Athletic Recovery
Protocol Reference
Dose
100-300mcg
Frequency
1x daily
Half-life
~15 minutes (in vitro)
Route
Subcutaneous · IV · Nasal
Evidence
Emerging / Preclinical / Limited modern research; most studies date from 1980s–2000s with limited recent Western research (disputed)
Research References· 1
Research Models
HumanRabbit
Also in Nootropic & Neuro