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Catalog11 refs

MGF

Healing & RecoverytherapeuticResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Mechanosensitive Splice Variant Of IGF-1 Produced By Muscle In Response To Mechanical Loading. Exhibits Local Paracrine Effects On Satellite Cells.
Half-life
14
Uses
100
Typical
Body Map
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MusclesJoints
Overview

Mechano Growth Factor (MGF) is a splice variant of insulin-like growth factor 1 (IGF-1) produced locally in muscle tissue in response to mechanical stress and damage. It acts as a local tissue repair factor that specifically activates satellite cells — muscle stem cells that fuse with damaged fibers to promote regeneration.

Primary Uses
muscle growth
healing
muscle repair
injury recovery
enhanced regeneration
anti-aging
sarcopenia research
neuroprotection
Muscle hypertrophy research
Mechanical load adaptation
Satellite cell activation
Injury-induced repair
Skeletal muscle remodeling
Periodontal regeneration
Protocol Reference
Dose
100–200 mcg per injection (local)
Frequency
Variable
Half-life
Mechanosensitive Splice Variant Of IGF-1 Produced By Muscle In Response To Mechanical Loading. Exhibits Local Paracrine Effects On Satellite Cells.
Route
Subcutaneous
Research References· 21
Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages
PubMedPMID 21354439. Mechanisms of Ageing and Development, 2007.
A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia
PubMedPMID 16195369. FASEB Journal, 2005.
Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite cell activation following local tissue damage
PubMedPMID 12665597. Journal of Physiology, 2003.
Research Models
HumanRatrodents
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