Catalog4 refs
P-21
Nootropic & NeuroResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Overview
P21 (also known as P021, Ac-DGGLAG-NH2) is a small synthetic peptide reverse-engineered from the most active region of ciliary neurotrophic factor (CNTF), with an adamantane group to improve stability and brain penetration. It is a peptidergic CNTF mimetic studied as a neurogenic and neurotrophic compound for Alzheimer's disease and other memory disorders. In rodent studies it boosts neurogenesis in the dentate gyrus of the hippocampus and raises BDNF, apparently by inhibiting LIF signaling, which in turn dampens GSK-3 beta activity and reduces tau hyperphosphorylation. Also known as: P21.
Primary Uses
Neuroprotection
Neurogenesis and BDNF-linked research
Cognition/memory studies
Alzheimer-related models
Promotes neurogenesis in the dentate gyrus
Increases BDNF expression
Reduces tau protein pathology
Reduces amyloid-beta plaque formation
Improves cognitive function and memory
Restores synaptic deficits in cortex and hippocampus
Reduces mortality rate in Alzheimer's disease models
Prevents neurodegeneration during synaptic compensation period
Reduces age-related cognitive decline
Alzheimer's disease pathology reduction
Memory enhancement
Neurogenesis stimulation
Down syndrome models
CDKL5 deficiency models
Cognitive impairment prevention
Synaptic and dendritic deficit prevention
Protocol Reference
Dose
500 mcg - 1 mg
Frequency
1-2x daily
Half-life
Not Well Characterized
Route
Intranasal
Evidence
Emerging / Preclinical - Development ongoing (disputed)
Research References· 4
https://pubmed.ncbi.nlm.nih.gov/39592934/
PubMedPMID 39592934- [https://pmc.ncbi.nlm.nih.gov/articles/PMC5377379/](https://pmc.ncbi.nlm.nih.gov/articles/PMC5377379/)
https://pubmed.ncbi.nlm.nih.gov/25046994/
PubMedPMID 25046994- [https://pubmed.ncbi.nlm.nih.gov/28655344/](https://pubmed.ncbi.nlm.nih.gov/28655344/)
Research Models
mousemicerodents
Also in Nootropic & Neuro