Catalog11 refs
Pinealon
BioregulatorsCognition, Mood & NeuroprotectionnootropicNootropic & NeuroResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
cellstelomeresMitochondria
Overview
Pinealon (EDR, Glu-Asp-Arg) is a synthetic tripeptide from the Russian peptide-bioregulator family designed to mimic short signaling peptides found in brain tissue. It is proposed to work as an epigenetic regulator that enters cells and influences gene expression and protein synthesis. In neuronal cell models it reduces the buildup of reactive oxygen species under oxidative stress, functioning as an antioxidant and stress-protector. Reported downstream effects include less necrotic and apoptotic cell death and altered timing of ERK 1/2 signaling and the cell cycle. Research is preclinical and concentrated in Russian peptide-bioregulator literature with no published human trials.
Primary Uses
Sleep regulation and circadian rhythm normalization
Melatonin synthesis normalization in the pineal gland
Improving sleep architecture and reducing sleep latency
Neuroprotection against oxidative stress and excitotoxicity
Modulating neuronal survival and neurotransmitter metabolism gene expression
Cognitive function support in aging
Normalizing age-related decline in pineal function
cognitive enhancement
sleep regulation
neuroprotection
pineal gland function support
antioxidant defense in neuronal cells
anti-apoptotic protection in neurodegeneration models
Cognitive aging research
Epigenetic regulation
Stress resilience
Protection from prenatal hyperhomocysteinemia
Increasing cell viability by suppression of free radical levels
Activating proliferative processes
Regulation of cytokines and caspase-3 activity in brains under hypoxia
Influence on behavior and neurochemical processes in aged rats under hypoxia and hypothermia
Peptide regulation of gene expression
Neuroprotective effects in Alzheimer's disease models
Correction of hyperhomocysteinemia-induced disturbances of hypothalamic norepinephrine
Effect on learning and NMDA receptor subunit gene expression in hippocampus in diabetes models
Regulation of pro- and antioxidant enzyme gene expression in diabetes models
Traumatic brain injury recovery
Memory enhancement
Anti-aging and cellular senescence reduction
Biological age marker improvement
Anti-aging Effects
Antioxidant / oxidative stress reduction
Cognitive support
Pineal gland regulation
Sleep regulation support
Neuron protection from oxidative stress
Protocol Reference
Dose
2 mg daily
Frequency
Once Daily
Half-life
Short (tripeptide)
Route
Oral · Subcutaneous
Evidence
Preclinical / Limited — primarily from in vitro studies and small Russian clinical studies / Well Studied / C (disputed)
Research References· 18
Research Models
HumanMouseRatanimal (in vitro)animal modelshuman (in vitro)macaques
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