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Testagen

BioregulatorsReproductiveRussian bioregulatory peptideResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Variable (complex)
Half-life
25
Uses
100
Typical
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Overview

Testagen is a synthetic Khavinson tetrapeptide (Lys-Glu-Asp-Gly, KEDG) marketed as a testicular bioregulator for male reproductive and hormonal support. It is proposed to enter the cell nucleus, bind short DNA sequences, and tune gene expression in testicular tissue, supporting steroidogenesis (testosterone production by Leydig cells) and spermatogenesis. Evidence is limited to one small Russian clinical report and theoretical framework, with no independent replication or Western randomized controlled trials.

Primary Uses
Male reproductive support research
Spermatogenesis models
Testicular aging
Androgen-axis support
Testosterone synthesis induction in androgenic deficiency
Chronic abacterial prostatitis with androgenic deficiency
Promotes testosterone biosynthesis
Stimulates Leydig cell activity
Improves testicular cellular metabolism
Restores HPG axis communication
Supports spermatogenesis
Reduces prostatic inflammation
Enhances male reproductive balance
May normalize testosterone at any age
Male fertility support
Testicular function normalization
Sexual function enhancement
testicular research
testosterone support
testicular tissue support
Male reproductive health support
Testosterone production support
Spermatogenesis support
Androgenic deficiency
Chronic abacterial prostatitis
Protocol Reference
Dose
100–300 mcg
Frequency
Once Daily
Half-life
Variable (complex)
Route
Subcutaneous
Evidence
Preclinical / Moderate Research (disputed)
Research References· 9
https://pubmed.ncbi.nlm.nih.gov/11713572/
PubMedPMID 11713572- [https://www.mdpi.com/1420-3049/26/22/7053](https://www.mdpi.com/1420-3049/26/22/7053)
Relationships of Anemia, Serum Iron, and Serum Copper in Hospitalized Alpacas (Vicugna pacos).↗
Europe PMCPMID 41307871Biol Trace Elem Res2026
The Inhibitory Effect and Adsorption Properties of Testagen Peptide on Copper Surfaces in Saline Environments: An Experimental and Computational Study.↗
PubMedPMID 40807317Molecules2025Dobriţescu A, Samide A, Cioateră N, Mic OC, et al.
Research Models
HumanIn vitro
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