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Thymalin

BioregulatorsImmune & InflammationThymic Peptide Bioregulator | Immune ModulatorResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Complex mixture; not well characterized
Half-life
32
Uses
1
Typical
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Circulation
Overview

Thymalin is a natural peptide bioregulator derived from calf thymus gland, developed in the Soviet Union in the 1970s. It contains a mixture of thymic peptides that support immune restoration, anti-aging, and tissue regeneration. Research spanning decades has shown significant geroprotective effects, with studies demonstrating up to 2-fold reduction in mortality rates and 4-fold reduction when combined with Epithalamin.

Primary Uses
Immune system restoration
Anti-aging effects
Recovery of thymus gland function
Promotes maturation and differentiation of T-lymphocytes from thymic precursors
Restoring cellular immunity
Normalizes CD4/CD8 T-cell ratios
Stimulates phagocytic activity of neutrophils and macrophages
Enhancing innate immune surveillance
Reversing age-related thymic involution
Neuroendocrine regulation
Influencing melatonin and cortisol rhythms in elderly subjects
Immune restoration
Hematopoiesis studies
Aging immunology
Stress/infection recovery
Geroprotective effects
COVID-19 cytokine storm immunomodulation
Reparative osteogenesis
Antiviral therapy (herpes simplex virus epithelial keratitis)
Experimental coronavirus infection
Postoperative endometritis
Lymphopenia recovery
Respiratory illness prevention
Mortality reduction
Geroprotection
COVID-19 support
Antitumor effects
Thymus normalization
Immune support
Correcting immune deficiency
Reducing incidence of acute respiratory disease in elderly
Regulating immune status in severe COVID-19
Protocol Reference
Dose
1–5 mg/day
Frequency
Once daily for 5-10 day cycles
Half-life
Complex mixture; not well characterized
Route
Intramuscular
Evidence
Preclinical / Well Studied / Approved in Russia - Not FDA approved (disputed)
Research References· 17
https://pubmed.ncbi.nlm.nih.gov/19827673/
PubMedPMID 19827673### Research This Peptide Further
Research Literature \- Observed in studies ↗
PubMedPMID 14523363Courses repeated periodically
Reparative osteogenesis in mandible in cases of filling a bone defect with hydroxyapatite-containing osteotropic material and injecting the surrounding soft tissues with thymalin: experimental and morphological study.↗
PubMedPMID 38431810Wiad Lek2024Boiko AA, Malanchuk VA, Myroshnychenko MS
Research Models
AnimalHumananimal modelcow
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