Catalog5 refs
Thymosin Beta-4
Healing & RecoverytherapeuticTissue Repair & HealingHealingResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
SkinMusclesJointsmultiple systemsCirculation
Overview
Thymosin beta-4 (Tβ4) is a 43-amino-acid peptide that is one of the most abundant and highly conserved intracellular peptides in mammalian cells. It plays a central role in actin regulation, cell migration, wound healing, and tissue repair. Originally isolated from the thymus gland, thymosin beta-4 is now known to be present in virtually all nucleated cells. It is the parent molecule from which TB-500 (a synthetic fragment) is derived.
Primary Uses
Corneal wound healing
Cardiac repair after myocardial infarction
Pressure ulcer healing
Tissue repair and recovery
Wound healing
Anti-inflammatory effects
Angiogenesis
Anti-fibrotic tissue repair
Wound Healing Acceleration
Post-Surgical Recovery
Soft Tissue Injury Repair
Cardiac Protection Post-MI
Stroke Recovery Enhancement
General Regeneration
Dry eye
Neurotrophic keratopathy
Heart tissue repair
Hair growth
Tendon repair
Muscle repair
Protocol Reference
Dose
2.5-5 mg 2-3x weekly (community); 750 mcg - 1.5 mg daily (research studies)
Frequency
2-3x weekly
Half-life
~2 hours
Route
Subcutaneous injection · Topical (eye conditions)
Evidence
Clinical trials conducted (RegeneRx Biopharmaceuticals) for corneal wound healing, cardiac repair, and pressure ulcer healing / Well Studied / Phase III (disputed)
Research References· 4
https://pubmed.ncbi.nlm.nih.gov/25826322/
PubMedPMID 25826322- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315077/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315077/)
https://pubmed.ncbi.nlm.nih.gov/20536454/
PubMedPMID 20536454- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302647/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302647/)
Research Models
AnimalHumanPorcineRodentsanimalsmammalian cells
Also in Healing & Recovery