Catalog4 refs
Ziconotide
Healing & RecoveryPain ManagementHealingResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Overview
Ziconotide is a synthetic copy of omega-conotoxin MVIIA, a 25-amino-acid peptide with three disulfide bonds found in the venom of the cone snail Conus magus. It blocks N-type voltage-gated calcium channels on pain-sensing nerves in the spinal cord's dorsal horn, stopping the release of pain-signaling neurotransmitters. It is FDA approved for severe chronic pain.
Primary Uses
severe chronic pain
refractory pain conditions
Intrathecal therapy for patients who cannot tolerate or no longer respond to other options including intrathecal morphine
Protocol Reference
Dose
0.1-19.2 mcg/day intrathecal; slow titration required
Frequency
Continuous via intrathecal pump
Route
Intrathecal infusion
Evidence
FDA Approved / FDA approved (disputed)
Research References· 2
Research Models
Human
Also in Healing & Recovery