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Epitalon

Longevity & MitochondrialtherapeuticAnti-AgingResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Not established (short peptide)
Half-life
15
Uses
5
Typical
Body Map
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cellschromosomesmultiple systems
Overview

Epitalon (also spelled epithalon or epithalone) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. It is based on the natural peptide epithalamin, which is produced by the pineal gland. Epitalon's primary research interest centers on its ability to activate telomerase — the enzyme that maintains telomere length — making it one of the most studied peptides in longevity and anti-aging research.

Primary Uses
anti-aging
telomere maintenance
melatonin regulation
circadian normalization
antioxidant gene expression upregulation
Telomere Extension
Cellular Rejuvenation
Lifespan Extension
Pineal Function Restoration
Neurogenesis Support
Retinal Protection
Thymus Regeneration
Immune Surveillance
Telomere lengthening
Delaying cellular senescence
Protocol Reference
Dose
5–10 mg daily
Frequency
2–3 courses per year
Half-life
Not established (short peptide)
Route
Subcutaneous · Intramuscular
Evidence
Limited scientific evidence / Limited human data / Well Studied (disputed)
Research References· 2
Effect of Epitalon on the lifespan increase in Drosophila melanogaster
PubMedPMID 12618085. Mechanisms of Ageing and Development, 2003.
Effect of Epitalon on biomarkers of aging, life span, and spontaneous tumor incidence in female Swiss-derived SHR mice
PubMedPMID 14501186. Biogerontology, 2003.
Research Models
Drosophila melanogasterHumanMouseanimalhuman cell cultures
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