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Epithalon

Longevity & MitochondrialBioregulatorsResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
~30 Minutes
Half-life
32
Uses
2 mg
Typical
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Mitochondria
Overview

Epithalon (also spelled Epitalon) is a synthetic four-amino-acid peptide, Ala-Glu-Asp-Gly (AEDG), modeled on a natural pineal gland extract. It came out of decades of Russian gerontology research led by Vladimir Khavinson and is marketed as an anti-aging compound that supposedly switches telomerase back on. It has no approval from the FDA, EMA, or other Western regulators, and the human evidence is thin. The headline claim is telomerase activation, allowing telomeres to lengthen. It is also proposed to influence melatonin production, antioxidant defenses, and gene expression in the pineal-hypothalamic axis.

Primary Uses
Activating telomerase
Supporting pineal gland function
Anti-aging effects
Extending telomere length and cellular replicative capacity
Reducing oxidative stress markers
Improving circadian rhythm regulation and sleep quality
Influencing hypothalamic-pituitary signaling
Telomerase activation and telomere maintenance
Anti-aging and longevity
Melatonin regulation and circadian normalization
Upregulation of endogenous antioxidant enzymes
Reduction of spontaneous tumor incidence in aging models
Telomerase and cellular aging studies
Circadian regulation
Oxidative-stress resilience
Geroprotection research
Telomere Extension
Cellular Rejuvenation
Lifespan Extension
Pineal Function Restoration
Neurogenesis Support
Retinal Protection
Thymus Regeneration
Immune Surveillance
Anti-aging
Telomere lengthening
Delaying cellular senescence
Telomerase activation
Melatonin production support
Antioxidant defense
Geroprotection
Neuroendocrine support
Protocol Reference
Dose
2 mg nightly
Frequency
Daily For 10 Days, Or Every 3 Days For 17 Days
Half-life
~30 Minutes
Route
Subcutaneous
Evidence
In Vitro / Preclinical / Preclinical / Limited human data; most evidence from Russian animal studies with limited Western clinical validation / Well Studied / Limited scientific evidence (disputed)
Research References· 20
https://pubmed.ncbi.nlm.nih.gov/40141333/
PubMedPMID 40141333- [https://en.wikipedia.org/wiki/Epitalon](https://en.wikipedia.org/wiki/Epitalon)
Research Literature \- Observed in studies ↗
PubMedPMID 12937682Cycles repeated 1-2x per year
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.↗
PubMedPMID 41490200J Am Acad Orthop Surg Glob Res Rev2026Rahman OF, Lee SJ, Seeds WA
Research Models
Drosophila melanogasterHumanIn vitroMouseRatanimalhuman cell cultures
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