Catalog11 refs
Humanin
Longevity & MitochondrialLongevity & Cellular HealththerapeuticAnti-AgingResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Mitochondria
Overview
A 24-amino-acid mitochondrial-derived peptide (MDP) encoded in the mitochondrial genome (16S rRNA gene). Discovered in 2001 as a survival factor for neurons exposed to Alzheimer's disease-related insults, humanin has since been found to have broad cytoprotective, anti-apoptotic, and metabolic regulatory properties. Along with MOTS-c, it represents a growing class of mitochondrial peptides that function as retrograde signaling molecules.
Primary Uses
Brain protection from amyloid-beta toxicity
Metabolic regulation
Cellular stress resistance
Neuroprotection in Alzheimer's disease pathology
Reducing oxidative stress in neuronal cells
Improving insulin sensitivity
Inhibiting Bax-mediated mitochondrial apoptosis
Modulating IGF-1 signaling
Neuroprotection (Alzheimer's disease, stroke)
Metabolic health (insulin sensitivity, diabetes)
Anti-aging and longevity biology
Cytoprotection and anti-apoptotic signaling
Mitochondrial retrograde signaling research
Mitochondrial signaling
Cytoprotection and anti-apoptosis research
Metabolic aging
Neuroprotection
Alzheimer's disease research
Cardioprotection in myocardial ischemia-reperfusion
Reproduction regulation
Prostate cancer therapeutic target research
Alzheimer's Disease Protection
Parkinson's Disease Support
General Neuroprotection
Lifespan Extension
Healthspan Improvement
Anti-Aging
Cytoprotection
Anti-Apoptosis
Mitochondrial Support
Reduced Oxidative Stress
Anti-aging research
Cell survival
Metabolic and age-related disease
Protects neurons against amyloid-beta toxicity
Shields retinal pigment epithelium cells from oxidative stress and senescence
Protective effects in models of cardiovascular disease and diabetes
Protocol Reference
Dose
100–500 mcg
Frequency
Once Weekly
Half-life
Approximately 30 minutes in mice; longer in some species
Route
Injection
Evidence
Preclinical - Extensive animal research / Preclinical / Preclinical (cell culture and animal models) / Moderate Research / B (disputed)
Research References· 20
https://pubmed.ncbi.nlm.nih.gov/29265109/
PubMedPMID 29265109- [https://jme.bioscientifica.com/view/journals/jme/50/1/R11.xml](https://jme.bioscientifica.com/view/journals/jme/50/1/R11.xml)
Research Models
C. elegansHumanMouseRatanimalsnaked mole-rats
Also in Longevity & Mitochondrial