Catalog3 refs
Exenatide
MetabolicWeight LossResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Overview
Exenatide is a synthetic 39-amino-acid peptide (copy of natural exendin-4) originally isolated from Gila monster saliva. It was the first GLP-1 receptor agonist approved for market, sold as Byetta (twice daily) and Bydureon (once weekly). It binds and activates the GLP-1 receptor, triggering glucose-dependent insulin secretion, suppressing excess glucagon, slowing gastric emptying, and increasing satiety. Unlike native GLP-1, exendin-4 resists DPP-4 enzyme degradation, giving it a half-life of roughly 2.4 hours.
Primary Uses
Treatment of type 2 diabetes
Weight loss
Type 2 diabetes (adults and pediatric 10-17)
Glucose-dependent insulin secretion
Suppressing excess glucagon
Slowing gastric emptying
Increasing satiety
Protocol Reference
Dose
5-10 mcg twice daily (IR) or 2 mg weekly (ER)
Frequency
Twice daily (IR) or once weekly (ER)
Half-life
~2.4 hours
Route
Subcutaneous injection
Evidence
FDA Approved / FDA approved for treatment of type 2 diabetes (disputed)
Research References· 1
Research Models
Human
Also in Metabolic