Glucagon-like peptide-1 (GLP-1)
MetabolicResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Overview
Endogenous incretin hormone released by L cells in small intestine. Rapidly degraded by DPP-4 enzyme (half-life ~2 minutes). GLP-1 binds to GLP-1 receptor on pancreatic beta cells, activating Gs proteins to increase cAMP, which enhances glucose-stimulated insulin secretion and promotes beta cell proliferation.
Primary Uses
Type 2 diabetes
Obesity
Glucose-stimulated insulin secretion
Glucagon suppression
Satiety and reduced appetite
Delayed gastric emptying
Beta cell proliferation and survival
Protocol Reference
Half-life
~2 minutes
Evidence
A
Research Models
Human
Also in Metabolic