Catalog7 refs
MK-677 (Ibutamoren)
Growth Hormone SecretagogueGrowth Hormone / IGF-1 AxisResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Muscles
Overview
An oral (non-injectable) compound that triggers growth hormone release by mimicking the hunger hormone ghrelin. Activates ghrelin receptors (GHS-R1a) on pituitary somatotrophs, triggering sustained GH release with preserved pulsatile pattern. Elevates IGF-1 levels by 40-60% in clinical studies, mediating anabolic effects on muscle, bone, and connective tissue. Research focuses on increasing growth hormone and IGF-1 levels, improving sleep quality, body composition, and bone density.
Primary Uses
Increasing growth hormone and IGF-1 levels
Improving sleep quality (REM sleep and stage IV deep sleep)
Improving body composition (increasing lean body mass, reducing fat mass)
Increasing bone mineral density
Enhancing recovery and cognitive function
Supporting muscle protein synthesis in catabolic states
Osteoporosis research
Growth hormone restoration
IGF-1 enhancement
Sleep quality improvement
Muscle preservation during caloric restriction
Fat-free mass increase
Metabolic rate elevation
Bone formation enhancement
Anti-aging
Protocol Reference
Dose
Start 12.5mg daily, increase to 25mg based on tolerance
Frequency
Once daily, preferably at bedtime on empty stomach
Half-life
~24 hours
Route
Oral
Evidence
Well Studied / Phase 2 (disputed)
Research Models
Human
Also in Growth Hormone Secretagogue