Catalog3 refs
MOTS-c
Longevity & MitochondrialLongevity & Cellular HealththerapeuticMitochondrial-Derived Peptide | Metabolic RegulatorMetabolicHormonalResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
MitochondriaMuscles
Overview
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA Type-C) is a mitochondrial-derived peptide consisting of 16 amino acids encoded within the mitochondrial genome. Discovered in 2015 by Dr. Changhan David Lee at the University of Southern California, it is the first mitochondrial-derived peptide shown to act as a signaling molecule regulating nuclear gene expression. MOTS-c activates AMPK, regulates folate metabolism, improves insulin sensitivity, and acts as an exercise mimetic.
Primary Uses
Metabolic health and energy regulation
Exercise performance enhancement
Longevity and cellular aging
Improving glucose uptake and fat oxidation in skeletal muscle
Restoring age-related muscle insulin resistance
Regulating stress-response genes via nuclear translocation
Fat loss
Anti-aging
Metabolic regulation
Insulin sensitivity improvement
Exercise mimetic effects
Body composition support
Exercise mimetic research
Insulin sensitivity
Mitochondrial stress adaptation
Healthy aging studies
Obesity and insulin resistance reduction
Age-dependent physical decline regulation
Metabolic disorder prevention
Ovarian cancer progression suppression
Anti-pulmonary fibrosis
Insulin Resistance
Type 2 Diabetes Support
Obesity Prevention
Age-Related Decline Reversal
Mitochondrial Biogenesis
Lifespan Extension
Running Performance
Muscle Homeostasis
Recovery Support
Metabolic research
Glucose metabolism enhancement
Fatty acid oxidation promotion
Mitochondrial function improvement
Anti-aging research
Exercise performance research
Improving insulin sensitivity
Protecting against diet-induced obesity
Enhancing exercise capacity
Metabolic health regulation
Protocol Reference
Dose
1 mg 3-5x weekly
Frequency
3x weekly (weeks 1-4 initial); 1x weekly (weeks 5-8 maintenance)
Half-life
~4 Hours (estimated)
Route
Subcutaneous
Evidence
Animal Models Primary / Phase 2 / Limited human data; most evidence from animal studies and cell culture / Well Studied / B / Preclinical (disputed)
Research References· 16
Research Models
HumanMouseRat
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