Catalog3 refs
NAD+
Longevity & MitochondrialLongevity & Cellular HealththerapeuticResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
cellsMitochondriaMusclesCirculation
Overview
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell, essential for cellular energy production, DNA repair, and regulation of aging-related pathways including sirtuins and PARPs. NAD+ levels decline significantly with age — by approximately 50% between ages 40 and 60 — and this decline is implicated in mitochondrial dysfunction, metabolic disease, and neurodegeneration. Injectable NAD+ supplementation has emerged as a research strategy to rapidly restore cellular NAD+ pools, bypassing the slower oral precursor pathway.
Primary Uses
Mitochondrial energy production
DNA repair
Cellular metabolism support
Anti-aging
Metabolic health
Insulin sensitivity support
Glucose metabolism support
Circadian clock regulation
Mitochondrial biogenesis
Autophagy promotion
Anti-aging and longevity
Neurodegeneration (Alzheimer's, Parkinson's, ALS)
Metabolic health (insulin sensitivity, glucose tolerance, hepatic fat reduction)
Cardiovascular protection (cardiac hypertrophy, endothelial function, vascular density)
Cellular energy production and mitochondrial function
DNA repair support
Cellular energy metabolism
Sirtuin-related research
Mitochondrial function
Age-related metabolic decline
Cellular Energy Production
Metabolic Optimization
Exercise Performance
Sirtuin Activation
Cellular Senescence Reduction
Cognitive Enhancement
Neuroprotection
Stress response
Metabolic support
Protocol Reference
Dose
50–100 mg per session
Frequency
2-3x weekly (titrated up)
Half-life
Route-dependent; not simply summarized by single plasma value
Route
Subcutaneous
Evidence
Mixed Evidence / Phase 4 / Extensively Studied / Clinical Trials (disputed)
Research References· 22
Research Models
HumanMouseRat
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