Catalog5 refs
Argireline
Cosmetic & DermalCosmeticSkin & HairResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
SkinMuscles
Overview
Argireline (acetyl hexapeptide-8, also called acetyl hexapeptide-3) is a synthetic peptide sold in anti-aging creams as a topical, needle-free alternative to Botox. It is a fragment that copies the N-terminal end of SNAP-25, competing for a place in the SNARE complex to blunt muscle firing that folds skin into wrinkles. It is a cosmetic ingredient, not an FDA-approved drug, with mixed human efficacy data.
Primary Uses
Wrinkle reduction
Softening expression lines
Topical alternative to botulinum toxin injections
Anti-wrinkle / anti-aging skincare
Topical alternative to botulinum toxin (Botox)
Protocol Reference
Dose
5-10% concentration in formulations
Frequency
Twice daily
Route
Topical (serums, creams)
Evidence
Preclinical / Phase 3 (disputed)
Research References· 1
Research Models
Human
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