Catalog3 refs
GHK-Cu
Cosmetic & DermalcosmeticSkin Regeneration & Anti-Aging CompoundSkin & HairResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
SkinJointsCirculation
Overview
GHK-Cu is the copper(II) complex of GHK, a naturally occurring human tripeptide (glycyl-L-histidyl-L-lysine) found in blood plasma, saliva and urine, whose levels decline with age. It is researched and widely used in cosmetic skincare for skin regeneration, wound healing, collagen support and anti-aging. It stimulates fibroblasts to produce collagen and other extracellular-matrix proteins, supports keratinocyte and blood-vessel activity, and shows antioxidant and anti-inflammatory effects. Its most striking documented activity is broad gene-expression modulation, upregulating tissue-repair genes and downregulating some inflammatory pathways.
Primary Uses
Wound healing
Skin regeneration
Anti-aging
Tissue repair
Collagen synthesis
Skin tightening and wrinkle reduction
Hair growth
Reduces inflammation
Reduces oxidative damage
Skin rejuvenation
Lung and tissue fibrosis
Dermal remodeling
Hair-growth studies
Wound repair
Copper-dependent regenerative signaling
Anti-wrinkle
Elastin production
Skin barrier function
Hair growth stimulation
Scalp health
Immune modulation
Tissue protection
Antioxidant protection
Skin repair and anti-aging
Collagen support
Antioxidant defense
Protocol Reference
Dose
1.7–2.0 mg daily
Frequency
Once Daily
Half-life
Topical Kinetics Undefined
Route
Subcutaneous · Topical
Evidence
Mixed Evidence / Phase 2 / Well Studied / B / Preclinical (disputed)
Research References· 25
https://pubmed.ncbi.nlm.nih.gov/18644225/
PubMedPMID 18644225- [https://pubmed.ncbi.nlm.nih.gov/25690343/](https://pubmed.ncbi.nlm.nih.gov/25690343/)
Research Models
HumanIn vitroRabbitRat
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