Catalog4 refs
Bivalirudin
OtherCardiovascularHormonalResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Overview
Bivalirudin is a synthetic 20 amino acid peptide based on hirudin, the natural anticlotting molecule from medicinal leeches. It is a direct thrombin inhibitor that blocks thrombin itself rather than working through antithrombin like heparin. It is bivalent, binding both thrombin's active catalytic site and exosite 1, inhibiting clot-bound thrombin as well as free-floating thrombin. FDA-approved anticoagulant (brand name Angiomax) given intravenously during PCI and in some acute coronary syndrome and heparin-induced-thrombocytopenia situations to prevent clots while keeping bleeding lower than older drugs.
Primary Uses
Anticoagulation during percutaneous coronary interventions (PCI)
Alternative to heparin with lower bleeding risk
PCI anticoagulation
Acute coronary syndrome
Heparin-induced thrombocytopenia
Prevention of ischemic events during stenting
Reducing bleeding complications after stenting
Protocol Reference
Dose
0.75 mg/kg IV bolus, 1.75 mg/kg/h infusion during procedure
Frequency
During procedure
Route
IV bolus and infusion
Evidence
FDA Approved / FDA approved (disputed)
Research References· 1
Research Models
Human
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