Colistin (polymyxin E)
OtherResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
bacterial cell membranes
Overview
Colistin is a cyclic lipopeptide antibiotic that binds to lipopolysaccharide (LPS) in Gram-negative outer membranes through electrostatic interactions, disrupting membrane integrity and causing cell death. It is reserved as a last-resort antibiotic for multidrug-resistant Gram-negative infections.
Primary Uses
Multidrug-resistant Gram-negative infections
Pseudomonas aeruginosa infections
Acinetobacter infections
Other resistant pathogen infections
Protocol Reference
Evidence
FDA approved as last-resort antibiotic
Research Models
Gram-negative bacteria
Also in Other