Hirudin
OtherResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Circulation
Overview
A 65-amino-acid peptide from medicinal leech (Hirudo medicinalis) saliva that binds tightly to thrombin's active site and exosite 1, irreversibly inhibiting thrombin's catalytic activity and preventing clot formation. It is one of the most potent thrombin inhibitors known and serves as a model for synthetic thrombin inhibitors like bivalirudin.
Primary Uses
Anticoagulation
Platelet activation inhibition
Thrombin inhibition
Protocol Reference
Dose
Not provided
Research Models
Hirudo medicinalis
Also in Other