Catalog3 refs
Matrixyl 3000
Cosmetic & DermalResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Skin
Overview
A cosmetic peptide complex consisting of Palmitoyl Tripeptide-1 (Pal-GHK) and Palmitoyl Tetrapeptide-7 (Pal-GQPR). Both are matrikines—short collagen-derived signals that skin treats as repair instructions. Palmitoyl tripeptide-1 stimulates fibroblasts to produce collagen, elastin, and fibronectin, while palmitoyl tetrapeptide-7 reduces interleukin-6 (IL-6), an inflammatory messenger that accelerates matrix breakdown. Palmitoyl tails help ferry the peptides through the skin barrier. Aimed at firmness, fine lines, and aging skin, with supportive but mostly manufacturer-generated evidence.
Primary Uses
Skin firmness
Fine lines and wrinkle reduction
Collagen synthesis stimulation
Anti-aging skincare
Reducing skin inflammation
Protocol Reference
Dose
2-8% in formulations
Frequency
Applied twice daily
Route
Topical (serums, creams)
Evidence
Preclinical
Research References· 2
https://pubmed.ncbi.nlm.nih.gov/18492182/
PubMedPMID 18492182- [https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1467-2494.2005.00261.x](https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1467-2494.2005.00261.x)
Research Models
Human
Also in Cosmetic & Dermal