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Melanotan 1 (Afamelanotide)
Cosmetic & DermalResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
Skin
Overview
Melanotan 1 (Afamelanotide) is a synthetic version of the natural skin-darkening hormone alpha-MSH. It is FDA-approved as Scenesse, a subcutaneous implant for treating EPP, a rare genetic condition causing extreme sun sensitivity. It is also commonly used via injection or nasal spray for tanning. Selectively activates MC1R receptors on melanocytes, stimulating eumelanin production for photoprotection without significant sexual side effects.
Primary Uses
Treating EPP (extreme sun sensitivity)
Tanning
Photoprotection
Reducing sunburn risk
Reducing UV-induced DNA damage
Skin cancer prevention
Anti-inflammatory effects
Protocol Reference
Dose
0.08–0.16 mg/kg (SC injection)
Frequency
Daily for 10 days (clinical trials)
Route
Subcutaneous (SC) · Nasal Spray · Subcutaneous implant
Evidence
Phase 4
Research Models
Human
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