Catalog4 refs
SNAP-8 (Acetyl Octapeptide-3)
Cosmetic & DermalSkin, Hair & AestheticsAnti-Wrinkle & Expression Line PeptideResearch use only
Educational use only. Not medical advice. Verify all information with primary sources and a licensed clinician before use.
Body Map
SkinMusclesnerves
Overview
SNAP-8 is an eight-amino-acid peptide used in cosmetic skincare to reduce wrinkles. It works by partially blocking nerve-to-muscle signaling in a way similar to botulinum toxin but through a different mechanism. It mimics the N-terminal of SNAP-25, competing with native protein in SNARE complex formation required for neurotransmitter release, reducing acetylcholine release at neuromuscular junctions, relaxing muscle contractions responsible for expression lines.
Primary Uses
Reducing dynamic wrinkles (forehead lines, crow's feet, frown lines)
Anti-wrinkle treatment
Relaxing expression muscles
Anti-Wrinkle
Expression Line Reduction
Forehead Wrinkle Treatment
Crow's Feet Improvement
Muscle Relaxation
SNARE Complex Modulation
Targeted Muscle Action
Preventive Anti-Aging
Wrinkle Reduction
Protocol Reference
Dose
3-10% topical concentration (0.33-1mg injectable)
Frequency
2x daily for topical (morning and evening)
Half-life
Not established (primarily topical use)
Route
topical · injectable
Evidence
Well Studied / Preclinical (disputed)
Research Models
human
Also in Cosmetic & Dermal